List of Publications 2003 - 2026

List of Publications

  • Spugnini EP, A Porrello. Potentiation of chemotherapy in companion animals with spontaneous large neoplasms by application of biphasic electric pulses. J. Exp. Clin. Canc. Res. 2003; 22: 571-580.
  • Spugnini EP, Dragonetti E, Vincenzi B, Onori E, Citro G, Baldi A. Pulse mediated chemotherapy enhances local control and survival in a spontaneous canine mucosal melanoma model. Melanoma Res. 2006; 16: 23-27.
  • Spugnini EP, Baldi A, Vincenzi B, Bongiorni F, Bellelli C, Citro G, Porrello A. Intraoperative versus postoperative electrochemotherapy in soft tissue sarcomas: a preliminary study in a spontaneous feline model. Cancer Chemother Pharmacol. 2007; 59 (3): 375-381.
  • Spugnini EP, Vincenzi B, Baldi F, Citro G, Baldi A. Adjuvant electrochemotherapy for the treatment of incompletely resected canine mast cell tumors. Anticancer Res. 2006; 26(6B) 4585-4889.
  • Spugnini EP, Vincenzi B, Citro G, Santini D, Dotsinsky I, Mudrov N, Montesarchio V, Laieta MT, Esposito V,Baldi A . Adjuvant electrochemotherapy for the treatment of incompletely excised spontaneous canine sarcomas. In Vivo 2007; 21: 819-822.
  • Spugnini EP, Filipponi M, Romani L, Dotsinsky I, Mudrov N, Baroni A, Ruocco E, Lieta MT, Montesarchio V,Cassandro R, Citro G, Baldi A. Local control and distant metastases after electrochemotherapy of a canine anal melanoma. In Vivo 2007; 21: 897-900.
  • Spugnini EP, Citro G, Mellone P, Dotsinsky I, Mudrov N, Baldi A. Electrochemotherapy for localized lymphoma: a preliminary study in companion animals. J Exp Clin Cancer Res 2007; 26: 343-346.
  • Spugnini EP, Arancia G, Porrello A, Colone M, Formisano G, Stringaro A, Citro G, Molinari A. Ultrastructural modifications induced by electroporation on melanoma xenografts. Micr Res Tech.2007; 70: 1041-1050.
  • Spugnini EP, Citro G, Dotsinsky I, Mudrov N, Mellone P, Baldi A. Ganglioneuroblastoma in a cat: a rare neoplasm treated with electrochemotherapy. Vet J 2008; 178: 291-293.
  • Spugnini EP, Vincenzi B, Citro G, Tonini G, Dotsinsky I, Mudrov N, Baldi A. Electrochemotherapy for the treatment of squamous cell carcinoma in cats: a preliminary report. Vet J 2009; 179: 117-120.
  • Spugnini EP, Vincenzi B, Betti G, Cordahi F, Dotsinsky I, Mudrov N, Citro G, Baldi A. Surgery and electrochemotherapy for high grade soft tissue sarcoma in a dog. Vet Rec 2008; 162: 186-188.
  • Spugnini EP, Dotsinsky I, Mudrov N, Cardosi G, Citro G, Baldi A. Biphasic pulses enhance bleomycin efficacy in a spontaneous canine perianal tumors model. J Exp Clin Cancer Res 2007; 26: 483-487.
  • Spugnini EP, Dotsinsky I, Mudrov N, Bufalini M, Giannini G, Citro G, Feroce F, Baldi A. Adjuvant electrochemotherapy for incompletely excised anal sac carcinoma in a dog. In Vivo 2008; 22:. 47-50
  • Spugnini EP, Dotsinsky I, Mudrov N, De Luca A, Codini C, Citro G, D’ Avino A, Baldi A. Successful rescue of an apocrine gland carcinoma metastatic to the cervical lymph nodes by mitoxantrone coupled with trains of permeabilizing electric pulses (electrochemotherapy). In Vivo 2008; 22: 51-54
  • Spugnini EP, Filipponi M, Romani L, Dotsinsky I, Mudrov N, Citro G, Baldi A. Bilateral pleomorphic rhabdomyosarcoma in a cat treated with electrochemotherapy. J Small An Pract 2010; 51(6):330-2
  • Spugnini EP, Vincenzi B, Citro G, Baldi A. Evaluation of cisplatin (CDDP) as a electrochemotherapy agent for the treatment of incompletely excised mast cell tumors in dogs. J Vet Intern Med, 2011; 25: 407-411.
  • Spugnini EP, Biroccio A, De Mori R, Scarsella M, D’ Angelo C, Baldi A, Leonetti C. Electroporation increases antitumoral efficacy of the bcl-2 antisense g3139 and chemotherapy in a human melanoma xenograft. J Trasl Med. 2011;9:152.
  • Spugnini EP, D’ Alterio GL, Dotsinsky I, Mudrov T, Dragonetti E, Murace G, Citro G, Baldi A. Electrochemotherapy for the treatment of multiple melanomas in a horse. J Eq Vet Sci. 2011; 31: 430-433.
  • Spugnini EP, Renaud SM, Buglioni S, Carocci F, Dragonetti E, Murace R, Cardelli P, Vincenzi B, Baldi A, CitroG. Electrochemotherapy with cisplatin enhances local control after surgical ablation of fibrosarcoma in cats: an approach to improve the therapeutic index of highly toxic chemotherapy drugs. J Transl Med. 2011; 9:152.
  • Spugnini EP, Cardillo I, Fanciulli M, Crispi S, Baldi A. Electroporation as a strategy to promote HtrA1 gene uptake and chemotherapy efficacy in a mouse model of mesothelioma. Front Biosci 2013; 5:974-81.
  • Spugnini EP, Di Tosto G, Salemme S, Pecchia L, Fanciulli M, Baldi A. Electrochemotherapy for the treatment of recurring aponeurotic fibromatosis in a dog. Can Vet J. 2013 Jun;54(6):606-9
  • Scacco L, Bolaffio C, Romano A, Fanciulli M, Baldi A, Spugnini EP. Adjuvant electrochemotherapy increases local control in a recurring equine anal melanoma. J Eq Vet Sci. 2013; 33: 637-639.
  • Spugnini EP, Melillo A, Quagliuolo L, Boccellino M, Vincenzi B, Pasquali P, Baldi A. Definition of novel electrochemotherapy parameters and validation of their in vitro and in vivo effectiveness. J Cell Physiol. 2014 Sep;229(9):1177-81. doi: 10.1002/jcp.24548. PubMed PMID: 24403005.
  • Spugnini EP, Baldi A. Electrochemotherapy in veterinary oncology: from rescue to first line therapy. Methods Mol Biol. 2014;1121:247-56.doi:10.1007/978-1-4614-9632-8_22. Review. PubMed PMID: 24510829.
  • Lanza A, Baldi A, Spugnini EP. Surgery and electrochemotherapy for the treatment of cutaneous squamous cell carcinoma in a yellow-bellied slider (Trachemys scripta scripta). J Am Vet Med Assoc. 2015 Feb 15;246(4):455-7. doi:10.2460/javma.246.4.455. PubMed PMID: 25632821.
  • Franchini D, Ciccarelli S, Assumma C, Laino I, Di Bello A, D'Abramo C, Perrone C, Spugnini EP. Electrical resistance measurement in feline cutaneous squamous cell carcinoma treated with electrochemotherapy: a pilot study. Sci Rep. 2026 Jun 26. doi: 10.1038/s41598-026-59069-7. Epub ahead of print. PMID: 42362705.
  • Franchini D, Ciccarelli S, Assumma C, Laino I, Di Bello A, D'Abramo C, Perrone C, Spugnini EP. Electrical resistance measurement in feline cutaneous squamous cell carcinoma treated with electrochemotherapy: a pilot study. Sci Rep. 2026 Jun 26. doi: 10.1038/s41598-026-59069-7. Epub ahead of print. PMID: 42362705.

Publications with Impact Factor

  • Spugnini EP, Donald E. Thrall, G. Sylvester Price , Nicholas J. Sharp, Karen Munana , Rodney L. Page . Primary irradiation of canine intracranial masses. Vet Radiol Ultras. 2000; 41: 377-80.
  • Spugnini EP, A Bartolazzi, D Ruslander. Seminoma with cutaneous metastases in a dog. J Am An Hosp Assoc . 2000; 36: 253-6.
  • Spugnini EP, D Ruslander, A Bartolazzi. Extraskeletal osteosarcoma in a cat. J Am Vet Med Assoc 2001; 219: 60-62.
  • Spugnini EP. Use of hyaluronidase for the treatment of extravasation of chemotherapeutic agents in six dogs. J Am Vet Med Assoc 2002; 221: 1437-1440.
  • Spugnini EP, A Porrello. Potentiation of chemotherapy in companion animals with spontaneous large neoplasms by application of biphasic electric pulses. J. Exp. Clin. Canc. Res. 2003; 22: 571-580.
  • Porrello A, Cardelli P, Spugnini EP. Pet models in cancer research: general principles. J. Exp. Clin. Canc. Res. 2004; 23, 2: 5-17.
  • Spugnini EP, Citro G, Porrello A. Rational design of new electrodes for electrochemotherapy. J. Exp. Clin. Canc. Res 2005; 24: 245-254.
  • Cardillo I, Spugnini EP,Verdina A, Galati R, Citro G, Baldi A. Cox and mesothelioma: an overview. Histol Histopathol. 2005; 20: 1267-1274.
  • Spugnini EP, Porrello A, Citro G, Baldi A. Cox-2 overexpression in canine tumors: potential therapeutic targets in oncology. Histol Histopathol. 2005; 20: 1309-1312.
  • Campioni M, Santini D, Tonini G, Murace R, Dragonetti E, Spugnini EP, Baldi A. Role of APAF-1, a key regulator of apoptosis, in melanoma progression and chemoresistance. Exp Dermatol.2005; 14: 811-818.
  • Spugnini EP, Dragonetti E, Murace R, Esposito V, Groeger AM, Baldi A. A spontaneous model of intestinal melanoma in dogs. In Vivo, 19: 1051-1054, 2005.
  • Porrello A, Cardelli P, Spugnini EP. Oncology of companion animals as a model for humans: an overview of tumor histotypes. J Exp Clin Cancer Res. 2006; 25: 97-106.
  • Spugnini EP, Esposito V, Groeger AM, Cassandro R, Chirianni A, Baldi A. Effects of Indinavir in a preliminary phase I study on dogs with stage III splenic hemangiosarcoma. In Vivo. 20: 125-128, 2006.
  • Esposito V, Palescandalo E, Spugnini EP, Montesarchio V, De Luca A, Cortese G, Baldi A, Chirianni A. Evaluation of antitumor properties of indinavir in a murine model of epatocarcinoma. Clin Cancer Res. 2006; 12 : 2634-2639.
  • Spugnini EP, Dragonetti E, Vincenzi B, Onori E, Citro G, Baldi A. Pulse mediated chemotherapy enhances local control and survival in a spontaneous canine mucosal melanoma model.Melanoma Res. 2006; 16: 23-27.
  • Spugnini EP, Baldi A, Vincenzi B, Bongiorni F, Bellelli C, Citro G, Porrello A. Intraoperative versus postoperative electrochemotherapy in soft tissue sarcomas: a preliminary study in a spontaneous feline model. Cancer Chemother Pharmacol. 2007; 59 (3): 375-381.
  • Baldi A, Colloca E, Spugnini EP. Lomustine for the treatment of gastrointestinal mast cell tumor in a dog. J Sm Anim Pract 2006; 47: 465-467.
  • Baldi A, Spugnini EP. Thoracic hemangiopericytoma in a cat. Vet Rec 2006; 159: 598-599.
  • Spugnini EP, Bosari S, Citro G, Cognetti F, Baldi A. Human malignant mesothelioma: molecular mechanisms of pathogenesis and progression. Int J Biochem Cell Biol 2006; 38: 2000-2004.
  • Spugnini EP, Cardillo I, Verdina A , Crispi S, Saviozzi S, Calogero R, Nebbioso A, Altucci L, Cortese G, Galati R, Chien J, Shridhar V, Vincenzi B, Citro G, Cognetti F, Sacchi A, Baldi A. Piroxicam inhibits the growth of mesothelioma cells and enhances platinum based chemotherapy in a mouse xenograft model of peritoneal mesothelioma. Clin Cancer Res 2006; 12: 6133-6143.
  • Esposito V, Campioni M, De Luca A, Spugnini EP, Baldi F, Cassandro R, Mancini A, Vincenzi B, Groeger A, Caputi M, Baldi A. Analysis of HTRA1 serine protease expression in human lung cancer.Anticancer Res. 2006; 26(5A): 3455-3459.
  • Spugnini EP, Vincenzi B, Baldi F, Citro G, Baldi A. Adjuvant electrochemotherapy for the treatment of incompletely resected canine mast cell tumors. Anticancer Res. 2006; 26(6B) 4585-4889.
  • Spugnini EP, Vincenzi B, Citro G, Santini D, Dotsinsky I, Mudrov N, Montesarchio V, Laieta MT, Esposito V, Baldi A . Adjuvant electrochemotherapy for the treatment of incompletely excised spontaneous canine sarcomas. In Vivo 2007; 21: 819-822.
  • Spugnini EP, Filipponi M, Romani L, Dotsinsky I, Mudrov N, Baroni A, Ruocco E, Lieta MT, Montesarchio V, Cassandro R, Citro G, Baldi A. Local control and distant metastases after electrochemotherapy of a canine anal melanoma. In Vivo 2007; 21: 897-900.
  • Spugnini EP, Citro G, Mellone P, Dotsinsky I, Mudrov N, Baldi A. Electrochemotherapy for localized lymphoma: a preliminary study in companion animals. J Exp Clin Cancer Res 2007; 26: 343-346.
  • Spugnini EP, Baldi F, Mellone P, Feroce F, Bonetto F, Citro G, Baldi A. Patterns of tumor responses in canine and feline cancer patients treated with electrochemotherapy. J Transl Med. 2007; Oct 2;5(1):48.
  • Turco MC, Lamberti A, Bisogni R, Romano MF, Petrella A, Ammirante M, Rosati A, Davenia M, Arra C, Spugnini E, Bonelli P, Venuta S. Modulation of cell apoptosis by AIR. Leukemia 2007; 21: 2557-2559.
  • Spugnini EP, Arancia G, Porrello A, Colone M, Formisano G, Stringaro A, Citro G, Molinari A. Ultrastructural modifications induced by “electroporation” on melanoma xenografts. Micr Res Tech.2007; 70: 1041-1050.
  • Spugnini EP, Citro G, Dotsinsky I, Mudrov N, Mellone P, Baldi A. Ganglioneuroblastoma in a cat: a rare neoplasm treated with electrochemotherapy. Vet J 2008; 178: 291-293.
  • Spugnini EP, Vincenzi B, Citro G, Tonini G, Dotsinsky I, Mudrov N, Baldi A. Electrochemotherapy for the treatment of squamous cell carcinoma in cats: a preliminary report. Vet J 2009; 179: 117-120.
  • Spugnini EP, Pagotto A, Zazzera F, D’ Avino A, Caruso G, Baldi A. Cutaneous T cell lymphoma in an African hedgehog (Atelerix Albiventris). In Vivo. 2008; 22: 43-46.
  • Spugnini EP, Citro G, Baldi A. Potential role of electrochemotherapy for the treatment of soft tissue sarcoma: first insights from preclinical studies in animals. Int J Biochem. Cell Biol. 2008; 40: 159-163.
  • Spugnini EP, Vincenzi B, Betti G, Cordahi F, Dotsinsky I, Mudrov N, Citro G, Baldi A. Surgery and electrochemotherapy for high grade soft tissue sarcoma in a dog. Vet Rec 2008; 162: 186-188.
  • Spugnini EP, Dotsinsky I, Mudrov N, Cardosi G, Citro G, Baldi A. Biphasic pulses enhance bleomycin efficacy in a spontaneous canine perianal tumors model. J Exp Clin Cancer Res 2007; 26: 483-487.
  • Spugnini EP, Campioni M, D’Avino A, Caruso G, Citro G, Baldi A. Cell-cycle molecules in mesothelioma: an overview. J Exp Clin Cancer Res 2007; 26: 443-449.
  • Spugnini EP, Dotsinsky I, Mudrov N, Bufalini M, Giannini G, Citro G, Feroce F, Baldi A. Adjuvant electrochemotherapy for incompletely excised anal sac carcinoma in a dog. In Vivo 2008; 22:. 47-50
  • Spugnini EP, Dotsinsky I, Mudrov N, De Luca A, Codini C, Citro G, D’ Avino A, Baldi A. Successful rescue of a apocrine gland carcinoma metastatic to the cervical lymph nodes by mitoxantrone coupled with trains of permeabilizing electric pulses (electrochemotherapy). In Vivo 2008; 22: 51-54
  • Spugnini EP, Crispi S, Scarabelli A, Caruso G, Citro G, Baldi A. Piroxicam and intracavitary platinum-based chemotherapy for the treatment of advanced mesothelioma in pets: preliminary observations. J Exp Clin Cancer Res 2008; 27: 6.
  • Spugnini EP, Vincenzi B, Caruso G, Baldi A, Citro G, Santini D, Tonini G. Zoledronic acid for the treatment of appendicular osteosarcoma in a dog. J Sm An Pract. 2009; 59: 44-46.
  • Baldi A, Mottolese M, Vincenzi B, Campioni M, Mellone P, Di Martino M,Di Crescenzo VC, Visca P, Menegozzo S, Spugnini EP, Citro G, Ceribelli A, Mirri A, Chien J, Schridhar V, Ehrmann M, Santini M, Facciolo F. The serine protease HTRA 1 is a novel prognostic factor for human mesothelioma. Pharmacogenomics 2008; 9: 1069-1077.
  • Spugnini EP, Dotsinsky I, Mudrov N, Citro G, D’ Avino A, Baldi A. Biphasic pulses enhance bleomycin efficacy in a spontaneous canine genital tumor model of chemoresistance: Sticker sarcoma.J Exp Clin Cancer Res 2008; 27: 58.
  • Campioni M, Ambrogi V, Pompeo E, Citro G, Castelli M, Spugnini EP, Gatti A, Cardelli P, Lorenzon L, Baldi A, Mineo TC. Identification of genes down-regulated during lung cancer progression: a cDNA array study. J Exp Clin Cancer Res. 2008 Sep 15;27:38.
  • Assin R, Baldi A, Citro G, Spugnini EP. Prostate as sole unusual recurrence site of lymphoma in a dog. In Vivo. 2008; 22: 755-757.
  • Spugnini EP, Dotsinsky I, Mudrov N, Citro G, Cardelli P, Caruso G, Baldi A. Electrochemotherapy-Induced radiation recall in a cat. In Vivo. 2008; 22: 751-753.
  • Spugnini EP, Gargiulo M, Assin R, D’ Avino A, Mellone P, Cardelli P, Citro G, Baldi A. Adjuvant carboplatin for the treatment of intestinal carcinoid in a dog. In Vivo. 2008; 22: 759-761.
  • Spugnini EP, Citro G, Baldi A. Adjuvant electrochemotherapy in veterinary patients: a model for the planning of future therapies in humans. J Exp Clinical Cancer Res 2009; 28: 114.
  • Crispi S, Cardillo I, Spugnini EP, Citro G, Menegozzo S, Baldi A. Biological Agents Involved in Malignant Mesothelioma: Relevance as Biomarkers or Therapeutic Targets. Curr Cancer Drug Targets. 2010; 10(1):19-26
  • Spugnini EP, Filipponi M, Romani L, Dotsinsky I, Mudrov N, Citro G, Baldi A. Bilateral pleomorphic rhabdomyosarcoma in a cat treated with electrochemotherapy. J Small An Pract 2010; 51(6):330-2
  • Signorile PG, Spugnini EP, Mita L, Mellone P, D’Avino A, Bianco M, Diano N, Caputo L, Rea F, Viceconte R, Portaccio M, Viggiano E, Citro G, Pierantoni R, Sica V, Vincenzi B, Mita DG, Baldi F, Baldi A. Prenatal exposure of mice to bisphenol a elicits an endometriosis-like phenotype in female offspring. Gen Comp Endocrinol 2010 168(3):318-325.
  • Spugnini EP, Mezzanotte F, Freri L, Betti G, Citro G, Baldi A. Cyproterone acetate-induced mammary carcinoma in two male cats. J Feline Med Surg 2010;12: 515-516.
  • Spugnini EP, Citro G, Fais S. Proton pump inhibitors as anti vacuolar-ATPases drugs: a novel anticancer strategy. J Exp Clin Cancer Res. 2010 May 8;29:44.
  • Aulino P, Berardi E, Cardillo VM, Rizzuto E, Perniconi B, Ramina C, Padula F, Spugnini EP, Baldi A, Faiola F, Adamo S, Coletti D. Molecular, cellular and physiological characterization of the cancer cachexia-inducing C26 colon carcinoma in mouse. BMC Cancer. 2010; 10:363.
  • Baldi A, De Luca A, Esposito V, Campioni M, Spugnini EP, Citro G. Tumor suppressors and cell-cycle proteins in lung cancer. Pathology Research International. 2011; 2011: 605042.
  • Spugnini EP, Vincenzi B, Citro G, Baldi A. Evaluation of cisplatin (CDDP) as a electrochemotherapy agent for the treatment of incompletely excised mast cell tumors in dogs. Journal of Veterinary Internal Medicine, 2011; 25: 407-411.
  • Spugnini EP, Biroccio A, De Mori R, Scarsella M, D’ Angelo C, Baldi A, Leonetti C. Electroporation increases antitumoral efficacy of the bcl-2 antisense g3139 and chemotherapy in a human melanoma xenograft. Journal of Translational Medicine. 2011;9:152.
  • Spugnini EP, D’ Alterio GL, Dotsinsky I, Mudrov T, Dragonetti E, Murace G, Citro G, Baldi A. Electrochemotherapy for the treatment of multiple melanomas in a horse. Journal of Equine Veterinary Science. 2011; 31: 430-433.
  • Mara Campioni, Anna Severino, Lucrezia Manente, Antonio De Luca, Raffaele La Porta, Antonio Vitiello, Paola Fiore, Stefano Toldo, Enrico P. Spugnini, Marco G. Paggi, Alfonso Baldi. Identification of protein-protein interactions of human HtrA1. Frontiers in Bioscience. 2011; 3:1493-1499.
  • Alfonso Baldi, Maria Rosaria Boccellino, Aldo Donizetti, Maria Teresa Piccolo, Raffaele La Porta, Lucio Quagliuolo, Enrico P. Spugnini, Irene Cardillo, Francesca Cordero, Gennaro Citro, Massimo Menegozzo, Raffaele A. Calogero, Stefania Crispi. Apoptosis induced by Piroxicam plus Cisplatin combined treatment is triggered by p21 overexpression in mesothelioma. PlosOne, 2011;6(8):e23569.
  • Mita L, Baldi A, Diano N, Viggiano E, Portaccio M, Nicolucci C, Grumiro L, Menale C, Mita DG, Spugnini EP, Viceconte R, Citro G, Pierantoni R, Sica V, Marino M, Signorile PG, Bianco M. Differential accumulation of BPA in some tissues of offspring of Balb-C mice exposed to different BPA doses. Environ Toxicol Pharmacol. 2011; 33(1):9-15.
  • Spugnini EP, Renaud SM, Buglioni S, Carocci F, Dragonetti E, Murace R, Cardelli P, Vincenzi B, Baldi A, Citro G. Electrochemotherapy with cisplatin enhances local control after surgical ablation of fibrosarcoma in cats: an approach to improve the therapeutic index of highly toxic chemotherapy drugs. J Transl Med. 2011; 9:152.
  • Enrico P Spugnini, Alfonso Baldi, Sabrina Buglioni, Francesca Carocci, Giulia Milesi de Bazzichini, Gianluca Betti, Ilaria Pantaleo, Francesco Menicagli, Gennaro Citro and Stefano Fais. Lansoprazole as a rescue agent in chemoresistant tumors: a phase I/II study in companion animals with spontaneously occurring tumors. J. Transl Med. 2011; 9:221.
  • Pietro G. Signorile, Enrico P. Spugnini, Gennaro Citro, Rosa Viceconte, Bruno Vincenzi, Feliciano Baldi, Alfonso Baldi. Endocrine disruptors in utero cause ovarian damages linked to endometriosis Baldi, Frontiers in Bioscience. 2012; 4:1724-30.
  • Stefania Meschini, Maria Condello, Pasquale Lista, Bruno Vincenzi, Alfonso Baldi, Gennaro Citro, Giuseppe Arancia, Enrico P. Spugnini. Electroporation adopting trains of biphasic pulses enhances in vitro and in vivo the cytotoxic effect of doxorubicin on multidrug resistant colon adenocarcinoma cells (LoVo) European Journal Of Cancer 2012 Sep;48(14):2236-43.
  • Vincenzo Esposito, Alessandra Verdina, Enrico P. Spugnini, Rosaria Viglietti, Roberto Parrella, Pasquale Pagliano, Giovanni Parrella, Rossella Galati, Antonio De Luca, Alfonso Baldi, Vincenzo Montesarchio, Antonio Chirianni. Amprenavir PI3K/AKT independent anti-tumoral properties in an in vitro and in vivo model of hepatocellular carcinoma. J Cell Physiol accepted for publication.
  • Spugnini EP, Fanciulli M, Citro G, Cardelli P, Baldi A. Electrochemotherapy in veterinary patients: a model for the implementation of loco-regional therapies in humans. Future Oncology 2012 Jul;8(7):829-37.
  • Spugnini EP, Cardillo I, Fanciulli M, Crispi S, Vincenzi B, Boccellino M, Quagliuolo L, Baldi A. Electroporation as a strategy to promote HtrA1 gene uptake and chemotherapy efficacy in a mouse model of mesothelioma. Frontiers in Bioscience accepted for publication.
  • Scacco L, Bolaffio C, Romano A, Fanciulli M, Baldi A,Spugnini EP. Adjuvant electrochemotherapy increases local control in a recurring equine anal melanoma.Journal of Equine Veterinary Science. Accepted for publication.
  • Spugnini EP, Di Tosto G, Salemme S, Pecchia L, Fanciulli M, Baldi A. Electrochemotherapy for the treatment of recurring aponeurotic fibromatosis in a dog.Canadian Veterinary JournalUnder revision
  • Spugnini EP, Melillo A, Quagliuolo L, Boccellino M, Vincenzi B, Pasquali P, Baldi A. Definition of Novel Electrochemotherapy Parameters and Validation of their In Vitro and In Vivo Effectiveness. J Cell Physiol. 2014 Jan 9.
  • Spugnini EP, Baldi A. Electrochemotherapy in veterinary oncology: from rescue to first line therapy. Methods Mol Biol. 2014;1121:247-56.
  • Spugnini EP, Buglioni S, Carocci F, Francesco M, Vincenzi B, Fanciulli M, Fais S. High dose lansoprazole combined with metronomic chemotherapy: a phase I/II study in companion animals with spontaneously occurring tumors. J Transl Med. 2014; 12:225.
  • Spugnini EP, Sonveaux P, Stock C, Perez-Sayans M, De Milito A, Avnet S, Garcì­a AG, Harguindey S, Fais S. Proton channels and exchangers in cancer. Biochim Biophys Acta. 2014 Oct 20 [Epub ahead of print].
  • Lanza A, Baldi A, Spugnini EP. Surgery and electrochemotherapy for the treatment of cutaneous squamous cell carcinoma in a yellow-bellied slider (Trachemys scripta scripta). J Am Vet Med Assoc. 2015 Feb 15;246(4):455-7.
  • Lugini L, Federici C, Borghi M, Azzarito T, Marino ML, Cesolini A, Spugnini EP, Fais S. Proton pump inhibitors while belonging to the same family of generic drugs show different anti-tumor effect. J Enzyme Inhib Med Chem. 2015 May 28:1-8.[Epub ahead of print]
  • Spugnini EP, Pizzuto M, Filipponi M, Romani L, Vincenzi B, Menicagli F, Lanza A, De Girolamo R, Lomonaco R, Fanciulli M, Spriano G, Baldi A. Electroporation Enhances Bleomycin Efficacy in Cats with Periocular Carcinoma and Advanced Squamous Cell Carcinoma of the Head. J Vet Intern Med. 2015; 29(5):1368-75.
  • Walsh M, Fais S, Spugnini EP, Harguindey S, Abu Izneid T, Scacco L, Williams P, Allegrucci C, Rauch C, Omran Z. Proton pump inhibitors for the treatment of cancer in companion animals. J Exp Clin Cancer Res. 2015; 34:93.
  • Taylor S, Spugnini EP, Assaraf YG, Azzarito T, Rauch C, Fais S. Microenvironment acidity as a major determinant of tumor chemoresistance: Proton pump inhibitors (PPIs) as a novel therapeutic approach. Drug Resist Updat. 2015; 23:69-78.
  • Spugnini EP, Azzarito T, Fais S, Fanciulli M, Baldi A. Electrochemotherapy as first line cancer treatment: experiences from veterinary medicine in developing novel protocols Current Cancer Drug Targets. 2015;16(1):43-52.
  • Canitano A, Iessi E, Spugnini EP, Federici C, Fais S. Proton pump inhibitors induce a caspase-independent antitumor effect against human multiple myeloma. Cancer Lett. 2016;376(2):278-83.
  • Menicagli F, Lanza A, Sbrocca F, Baldi A, Spugnini EP. A case of advanced second-degree atrioventricular block in a ferret secondary to lymphoma. Open Vet J. 2016;6(1):68-70.
  • Gentileschi MP, Lattanzio C, Menicagli F, Vincenzi B, Cigliana G, Baldi A, Blandino G, Muti P, Fanciulli M, Spugnini EP. Dietary Protective Effects Against Hepatocellular Carcinoma Development in Mdr2-/- Knockout Mice. In Vivo. 2016;30(4):445-50.
  • Azzarito T, Lugini L, Spugnini EP, Canese R, Gugliotta A, Fidanza S, Fais S. Effect of Modified Alkaline Supplementation on Syngenic Melanoma Growth in CB57/BL Mice. PLoS One. 2016;11(7):e0159763.
  • Spugnini EP, Fais S, Azzarito T, Baldi A. Novel Instruments for the Implementation of Electrochemotherapy Protocols: From Bench Side to Veterinary Clinic. J Cell Physiol. 2017 Mar;232(3):490-495.
  • Lugini L, Sciamanna I, Federici C, Iessi E, Spugnini EP, Fais S. Antitumor effect of combination of the inhibitors of two new oncotargets: proton pumps and reverse transcriptase. Oncotarget. 2017 Jan 17;8(3):4147-4155.
  • Spugnini EP, Bolaffio C, Scacco L, Baldi A. Electrochemotherapy increases local control after incomplete excision of a recurring penile fibrosarcoma in a stallion. Open Vet J. 2016;6(3):234-237.
  • Spugnini EP, Fais S. Proton pump inhibition and cancer therapeutics: A specific tumor targeting or it is a phenomenon secondary to a systemic buffering? Semin Cancer Biol. 2017 Jan 11. pii: S1044-579X(17)30003-2.
  • Lanza A, Pettorali M, Baldi A, Spugnini EP. Surgery and electrochemotherapy treatment of incompletely excised mammary carcinoma in two male pet rats (Rattus norvegicus). J Vet Med Sci. 2017 Mar 23;79(3):623-625.
  • Iessi E, Logozzi M, Lugini L, Azzarito T, Federici C, Spugnini EP, Mizzoni D, Di Raimo R, Angelini DF, Battistini L, Cecchetti S, Fais S. Acridine Orange/exosomes increase the delivery and the effectiveness of Acridine Orange in human melanoma cells: A new prototype for theranostics of tumors. J Enzyme Inhib Med Chem. 2017 Dec;32(1):648-657.
  • Spugnini EP, Menicagli F, Pettorali M, Baldi A. Ultrasound guided electrochemotherapy for the treatment of a clear cell thymoma in a cat. Open Vet J. 2017;7(1):57-60.
  • Spugnini EP, Bolaffio C, Scacco L, Baldi A. Isolated limb perfusion electrochemotherapy for the treatment of an advanced squamous cell carcinoma of the hoof in a mare. Open Vet J. 2017;7(2):192-196.
  • Pasquali P, Freites-Martinez A, Gonzalez S, Spugnini EP, Baldi A. Successful treatment of plantar warts with intralesional bleomycin and electroporation: pilot prospective study. Dermatol Pract Concept. 2017 Jul 31;7(3):21-26.
  • Pasquali P, Spugnini EP, Baldi A. Successful Treatment of a Keratoacanthoma with Electrochemotherapy: A Case Report. Dermatol Ther (Heidelb). 2018 Mar;8(1):143-146.
  • Carafa V, Nebbioso A, Cuomo F, Rotili D, Cobellis G, Bontempo P, Baldi A, Spugnini EP, Citro G, Chambery A, Russo R, Ruvo M, Ciana P, Maravigna L, Shaik J, Radaelli E, De Antonellis P, Tarantino D, Pirolli A, Ragno R, Zollo M, Stunnenberg HG, Mai A, Altucci L. RIP1-HAT1-SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer. Clin Cancer Res. 2018 Jun 15;24(12):2886-2900.
  • Baldi A, Lanza A, Menicagli F, Signorile PG, Spugnini EP. Histological and Immunohistochemical Characterization of a Case of Endometriosis in a Guinea Pig (Cavia tschudii). Case Rep Vet Med. 2017 May 8; 2017:4594510.
  • Spugnini EP, Lanza A, Sebasti S, Baldi A. Electrochemotherapy palliation of an oral squamous cell carcinoma in an African hedgehog (Atelerix albiventris). Vet Res Forum. 2018;9(4):379-381.
  • Spugnini EP, Logozzi M, Di Raimo R, Mizzoni D, Fais S. A Role of Tumor-Released Exosomes in Paracrine Dissemination and Metastasis. Int J Mol Sci. 2018;19(12):3968
  • Lanza A, Baldi A, Rossi G, Spugnini EP. Electrochemotherapy for the treatment of an incompletely excised subcutaneous low-grade epithelioid hemangioendothelioma in a budgerigar parakeet (Melopsittacus undulatus). Open Vet J. 2019 Oct;9(3):269-272.
  • Condello M, Pellegrini E, Spugnini EP, Baldi A, Amadio B, Vincenzi B, Occhionero G, Delfine S, Mastrodonato F, Meschini S. Anticancer activity of "Trigno M", extract of Prunus spinosa drupes, against in vitro 3D and in vivo colon cancer models. Biomed Pharmacother. 2019t;118:109281.
  • Spugnini EP, Baldi A Electrochemotherapy in Veterinary Oncology: State-of-the-Art and Perspectives. Vet Clin North Am Small Anim Pract. 2019;49(5):967-979.
  • Pillai SR, Damaghi M, Marunaka Y, Spugnini EP, Fais S, Gillies RJ. Causes, consequences, and therapy of tumors acidosis. Cancer Metastasis Rev. 2019;38(1-2):205-222.
  • Logozzi M, Spugnini EP, Mizzoni D, Di Raimo R, Fais S. Extracellular acidity and increased exosome release as key phenotypes of malignant tumors. Cancer Metastasis Rev. 2019; 38(1-2):93-101.
  • Spugnini EP, Vincenzi B, Amadio B, Baldi A. Adjuvant electrochemotherapy with bleomycin and cisplatin combination for canine soft tissue sarcomas: A study of 30 cases. Open Vet J. 2019;9(1):88-93.
  • Spugnini EP, Fais S. Drug repurposing for anticancer therapies. A lesson from proton pump inhibitors. Expert Opin Ther Pat. 2020 Jan;30(1):15-25.
  • Spugnini EP, Scimeca M, Amadio B, Cortese G, Fanciulli M, Vincenzi B, De Luca A, Baldi A. Definition of a Novel Plasmid-Based Gene Transfection Protocol of Mammalian Skeletal Muscles by Means of In Vivo Electroporation. Int J Mol Sci. 2020; 21(18):6494.
  • Dos Anjos DS, Sierra OR, Spugnini EP, De Nardi AB, Fonseca-Alves CE. Comparison of two different doses of bleomycin in electrochemotherapy protocols for feline cutaneous squamous cell carcinoma nonsegregated from ultraviolet light exposure. Sci Rep. 2020; 10(1):18362.
  • Dos Anjos DS, Buosi RG, Roratto I, Mesquita LDR, Matiz ORS, Fonseca-Alves CE, Spugnini EP. Preliminary assessment of electrochemotherapy feasibility in dogs with vesical transitional cell carcinoma. Vet Res Forum. 2020; 11(3):289-293.
  • Bruno T, De Nicola F, Corleone G, Catena V, Goeman F, Pallocca M, Sorino C, Bossi G, Amadio B, Cigliana G, Ricciardi MR, Petrucci MT, Spugnini EP, Baldi A, Cioce M, Cortese G, Mattei E, Merola R, Gianelli U, Baldini L, Pisani F, Gumenyuk S, Mengarelli A, Höpker K, Benzing T, Vincenzi B, Floridi A, Passananti C, Blandino G, Iezzi S, Fanciulli M. Che-1/AATF-induced transcriptionally active chromatin promotes cell proliferation in multiple myeloma. Blood Adv. 2020; 4(22):5616-5630.
  • Spugnini EP, Vincenzi B, Carocci F, Bonichi C, Menicagli F, Baldi A. Combination of bleomycin and cisplatin as adjuvant electrochemotherapy protocol for the treatment of incompletely excised feline injection-site sarcomas: A retrospective study. Open Vet J. 2020;10(3): 267-271.
  • Spugnini EP, Menicagli F, Giaconella R, Zanni F, Camponi C, De Luca A, Santoro A, Baldi A. Filling the gap between histology and cytology: description of an innovative technology (Cytomatrix) to increase the diagnostic effectiveness of fine needle aspirates data. J Clin Pathol. 2021; 74:269-270
  • Valenti P, Menicagli F, Baldi A, Barella G, Catalucci C, Attorri V, Spugnini EP. Evaluation of electrochemotherapy in the management of apocrine gland anal sac adenocarcinomas in dogs: A retrospective study. Open Vet J. 2021; 11(1):100-106.
  • Condello M, D’Avack G, Vona R, Spugnini EP, Scacco L, Meschini S. Electrochemotherapy with Mitomycin C Potentiates Apoptosis Death by Inhibiting Autophagy in Squamous Carcinoma Cells. Cancers 2021, 13, 3867.
  • Spugnini EP, Scacco L, Bolaffio C, Baldi A. Electrochemotherapy for the treatment of cutaneous solid tumors in Equids: A retrospective study. Open Vet J 2021, 11(3): 385-389
  • Spugnini EP, Menditti D, De Luca A, Baldi A. Electrochemotherapy in Translational Medicine: From Veterinary Experience to Human Oncology. Crit Rev Eukaryot Gene Expr. 2022; 33(1):79-90
  • Condello M, D'Avack G, Spugnini EP, Meschini S. Electrochemotherapy: An Alternative Strategy for Improving Therapy in Drug-Resistant SOLID Tumors. Cancers (Basel). 2022; 14:4341.
  • Spugnini EP, Condello M, Crispi S, Baldi A. Electroporation in Translational Medicine: From Veterinary Experience to Human Oncology. Cancers (Basel). 2024;16(5):1067.
  • Piccioni M, Di Meo F, Valentino A, Campani V, Arigoni M, Tanori M, Mancuso M, Cuciniello R, Tomasetti M, Monaco F, Goteri G, Spugnini EP, Calogero RA, De Rosa G, Peluso G, Baldi A, Crispi S. miRNA-503 inhibition exerts anticancer effects and reduces tumor growth in mesothelioma. J Exp Clin Cancer Res. 2025 Feb 22;44(1):65. doi: 10.1186/s13046-025-03283-0. PMID: 39984959; PMCID: PMC11846362.
  • Holanda AGA, Ruanova AV, Spugnini EP, Frasson MT, Fonseca-Alves CE, Anjos DSD. Successful treatment of cutaneous mast cell tumors in cats using electrochemotherapy: A case series. Open Vet J. 2025;15(7):3357-3365. doi: 10.5455/OVJ.2025.v15.i7.48. PMID: 41036372; PMCID: PMC12483410.
  • Amato FA, Spugnini EP, Attorri V, Catalucci C, Menicagli F, De Magistris AV, Valenti P. Electrochemotherapy for canine prostatic carcinoma treatment Open Vet J 2025; 15(9): 4540-4547 doi: 10.5455/OVJ.2025.v15.i9.60

Publications without Impact Factor

  • Spugnini EP, Page RL, Thrall DE. Canine Brain Tumors: a brief update. Veterinary Cancer Society Newsletter.1995. Volume 19, #3: 7-9.
  • Spugnini EP, Citro G, Baldi A. Cox Inhibitors as Potential Chemotherapeutic Drugs for Mesothelioma. Curre Resp Rev 2007; 3: 15-18.
  • Rosatelli P, Menicagli F, Citro G, Baldi A, Spugnini EP. Long term survival in a cat with pancreatic carcinoma and splenic involvement after surgical excision. Case Reports in Veterinary Medicine 2011; pp 1-3.
  • Spugnini EP. Improved delivery of anticancer molecules by means of biphasic electric pulses in laboratory animals and preclinical studies in companion animals with spontaneous neoplasms. Ph D thesis; February 2006, Sofia, Bulgaria.

Books

  • Spugnini EP, Baldi A, Citro G. Pulse mediated chemotherapy (electrochemotherapy) studies in animals and their translation to humans. Recent Res. Devel. Pharmacol. pp 1-28, 2006, Research Signpost, Kerala India.

  • Spugnini EP, Seiler G, Keene B. Canine mesothelioma: an epidemiological and preclinical model. In: Baldi A (Editor) "Mesothelioma from benchside to the clinic" Nova Science NY. 2008, pp 537-546

  • Spugnini EP et al. Chapters 7, 13, 14, 15. In: Electroporation in Laboratory and Clinical Investigations. Edited by Nova Science, New York.

  • Spugnini EP. Electrochemotherapy in dermatological Oncology. In: Skin Cancer: A Practical Approach. Edited by: Humana Press (Springer) New York USA pag 435-444.

  • Spugnini EP, Baldi A. Electrochemotherapy in veterinary oncology: from rescue to first line therapy. In: Electroporation Protocols Preclinical and Clinical Gene Medicine Series: Methods in Molecular Biology, Vol. 1121 pag 247-56. Li, S., Cutrera, J., Heller, R., Teissie, J. (Eds.) 2nd ed. 2014, Humana Press

  • Spugnini EP. Electrochemotherapy in feline oncology. In: Little S. (Editor). August consultations in feline internal medicine pag 572-577. Saunders Edition, Saint Louis, MO, USA.

  • Spugnini EP, Fais S. Vacuolar-ATPase proton pump inhibition in cancer therapy: veterinary and human experience. In: Koltai T, Reshkin SJ, Hardinguey S. (Editors) An innovative approach to understanding and treating cancer: targeting pH. From etiopathogenesis to new therapeutic avenues. Pp 509-522. 2020, Academic Press (Elsevier)